CAPN1

Across TCGA patient cohorts, CAPN1 mutation is significantly associated with the RNA expression of many other genes, with 2,851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAPN1-associated genes across cancer lineages are NOS2P1, RNU6-800P, and PRDX4P1. Each is linked with CAPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN1-to-partner and partner-to-CAPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOS2P1 grouped by CAPN1-low versus CAPN1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN1→partner) and Y-score (partner→CAPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NOS2P1 →	+0.065	+5.655	<.001	.004	3	2
GBM	RNU6-800P →	+0.523	+4.584	<.001	.007	3	2
HNSC	PRDX4P1 →	+0.101	+6.608	<.001	.001	3	2
GBM	LINC01455 →	+0.123	+4.865	.008	.002	3	2
BLCA	RNU1-57P →	+0.168	+4.040	<.001	.007	3	2
BLCA	MIR4477A →	+0.422	+2.457	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,851 associations by consensus.

NOS2P1 by CAPN1 expression — HNSC

Explore this box plot interactively →