CAPN1

Across TCGA cell cohorts, CAPN1 mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAPN1-associated genes across cancer lineages are KRTAP22-2, RAB19, and IQCF5. Each is linked with CAPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAPN1-to-partner and partner-to-CAPN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP22-2 grouped by CAPN1-low versus CAPN1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAPN1→partner) and Y-score (partner→CAPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KRTAP22-2 →	+0.100	+4.437	<.001	.004	3	2
LARGE_INTESTINE	RAB19 →	+0.882	+3.364	.001	.002	3	2
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
LUNG_NSCLC_LUAD	GABRG1 →	+0.559	+3.980	.001	.002	3	1
LUNG_NSCLC_LUAD	WFDC10A →	+0.433	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR14I1 →	+0.048	+3.481	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

KRTAP22-2 by CAPN1 expression — SKIN

Explore this box plot interactively →