CANX

Across TCGA patient cohorts, CANX mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CANX-associated genes across cancer lineages are GATA6, mTOR_pS2448, and eEF2. Each is linked with CANX in more than 1 cancer types. Because this analysis shows association rather than direction, both CANX-to-partner and partner-to-CANX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by CANX-low versus CANX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CANX→partner) and Y-score (partner→CANX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.172	-2.215	.008	.010	3	2
UCEC	mTOR_pS2448 →	-0.123	-1.807	.045	.027	3	2
UCEC	eEF2 →	+0.391	+2.999	.008	.035	3	1
UCEC	eIF4E →	+0.216	+2.321	.013	.006	3	1
UCEC	JNK2 →	+0.278	+2.321	<.001	.006	3	1
UCEC	MEK1 →	+0.463	+3.700	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GATA6 by CANX expression — UCEC

Explore this box plot interactively →