CANX

Across TCGA pan-cancer cohorts, CANX RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CANX’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CANX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CANX is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where CANX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CANX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.008	<.001	12	view →
THCA	Male	III,IV	−1.527	<.001	10	view →
LIHC	Female	II,III,IV	+1.436	<.001	9	view →
STAD	Male	II,III,IV	+0.902	<.001	8	view →
COAD	Male	II,III,IV	+0.680	<.001	8	view →
HNSC	All	All	+0.529	<.001	8	view →
LUAD	Male	All	+0.618	<.001	7	view →
BLCA	All	III,IV	+0.561	<.001	7	view →
BRCA	All	III,IV	+0.648	<.001	6	view →
KIRP	All	II,III,IV	+0.539	.010	4	view →
CHOL	All	All	+1.557	<.001	3	view →
PRAD	All	All	+0.380	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CANX–KIRC

Open the KIRC breakdown →