CANX

Across TCGA cell cohorts, CANX mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CANX-associated genes across cancer lineages are RHOXF2, BPIFB6, and OR2AT4. Each is linked with CANX in more than 1 cancer types. Because this analysis shows association rather than direction, both CANX-to-partner and partner-to-CANX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RHOXF2 grouped by CANX-low versus CANX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CANX→partner) and Y-score (partner→CANX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RHOXF2 →	+0.036	+3.544	<.001	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR2AT4 →	+0.015	+3.196	.006	.007	3	1
LARGE_INTESTINE	ASCL3 →	+0.178	+3.726	<.001	.004	3	1
LARGE_INTESTINE	NYX →	+0.065	+3.347	<.001	.005	3	1
LARGE_INTESTINE	OR2J1 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

RHOXF2 by CANX expression — LARGE_INTESTINE

Explore this box plot interactively →