CANT1

Across TCGA patient cohorts, CANT1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CANT1-associated genes across cancer lineages are p90 RSK, eEF2, and EGFR_pY1068. Each is linked with CANT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CANT1-to-partner and partner-to-CANT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by CANT1-low versus CANT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CANT1→partner) and Y-score (partner→CANT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.165	+2.179	.042	.034	3	2
UCEC	eEF2 →	+0.325	+2.999	.032	.035	3	1
UCEC	EGFR_pY1068 →	-0.216	-1.700	.043	.044	3	1
UCEC	ERK2 →	+0.187	+3.169	.022	.018	3	1
UCEC	JNK2 →	+0.245	+2.834	.003	.034	3	1
UCEC	Ku80 →	+0.200	+1.713	.046	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

p90 RSK by CANT1 expression — UCEC

Explore this box plot interactively →