CANT1

Across TCGA pan-cancer cohorts, CANT1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CANT1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CANT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CANT1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUAD, KIRP, and HNSC are the cancer types where CANT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CANT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.248	<.001	11	view →
KIRP	All	II,III,IV	+0.886	<.001	11	view →
HNSC	All	III,IV	+0.618	<.001	11	view →
BLCA	Male	III,IV	+1.522	<.001	10	view →
LIHC	Female	II,III,IV	+1.513	<.001	9	view →
LUSC	Male	II,III,IV	+0.807	<.001	7	view →
BRCA	All	III,IV	+1.280	<.001	6	view →
CHOL	Male	All	+2.786	<.001	5	view →
KICH	Female	II,III,IV	−0.897	<.001	5	view →
THCA	All	II,III,IV	+0.355	.002	5	view →
STAD	Male	All	+1.116	<.001	4	view →
PAAD	All	All	+0.459	.042	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CANT1–LUAD

Open the LUAD breakdown →