CANT1

Across TCGA cell cohorts, CANT1 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CANT1-associated genes across cancer lineages are IL4, C1QA, and TEX44. Each is linked with CANT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CANT1-to-partner and partner-to-CANT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL4 grouped by CANT1-low versus CANT1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CANT1→partner) and Y-score (partner→CANT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL4 →	+0.073	+3.217	<.001	.006	3	2
LUNG_SCLC	C1QA →	+0.203	+4.070	.003	.003	3	1
LUNG_SCLC	TEX44 →	+0.060	+4.247	.001	.005	3	1
LUNG_SCLC	OR10Q1 →	+0.392	+4.058	.001	.007	3	1
LUNG_SCLC	GDF3 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	C9orf92 →	+0.481	+3.523	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

IL4 by CANT1 expression — SKIN

Explore this box plot interactively →