CAND2

Across TCGA patient cohorts, CAND2 mutation is significantly associated with the RNA expression of many other genes, with 2,125 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAND2-associated genes across cancer lineages are CHEK2P1, GAS2L1, and ENO2. Each is linked with CAND2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAND2-to-partner and partner-to-CAND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK2P1 grouped by CAND2-low versus CAND2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAND2→partner) and Y-score (partner→CAND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHEK2P1 →	+0.129	+5.757	<.001	.001	3	3
COAD	GAS2L1 →	+0.753	+2.595	<.001	.006	3	3
UCEC	ENO2 →	+0.547	+1.936	.003	.002	3	3
UCEC	BCAR1 →	+0.293	+2.016	.007	.001	3	3
UCEC	ZNF511 →	+0.276	+1.676	.004	.003	3	3
UCEC	LINC00886 →	-0.369	-1.645	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,125 associations by consensus.

CHEK2P1 by CAND2 expression — BRCA

Explore this box plot interactively →