CAMLG

Across TCGA patient cohorts, CAMLG mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAMLG-associated genes across cancer lineages are Notch1, IGFBP2, and JNK2. Each is linked with CAMLG in more than 1 cancer types. Because this analysis shows association rather than direction, both CAMLG-to-partner and partner-to-CAMLG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CAMLG-low versus CAMLG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMLG→partner) and Y-score (partner→CAMLG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.230	+2.820	.001	.035	3	2
UCEC	IGFBP2 →	-1.070	-3.321	.001	.010	3	1
UCEC	JNK2 →	+0.209	+3.321	.045	.010	3	1
UCEC	Ku80 →	+0.244	+3.335	.049	.005	3	1
UCEC	MYH11 →	+1.261	+3.321	.036	.010	3	1
UCEC	VHL →	-0.865	-3.321	.015	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by CAMLG expression — UCEC

Explore this box plot interactively →