CAMK4

Across TCGA cell cohorts, CAMK4 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CAMK4-associated genes across cancer lineages are TIFAB, AGXT2, and RBM46. Each is linked with CAMK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CAMK4-to-partner and partner-to-CAMK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIFAB grouped by CAMK4-low versus CAMK4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAMK4→partner) and Y-score (partner→CAMK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TIFAB →	+0.005	+4.019	<.001	<.001	3	2
LUNG_NSCLC_LUAD	AGXT2 →	+0.015	+3.201	<.001	.004	3	1
LUNG_NSCLC_LUAD	RBM46 →	+0.569	+3.370	.001	.008	3	1
LUNG_NSCLC_LUAD	OR1Q1 →	+0.054	+4.345	.003	<.001	3	1
LUNG_NSCLC_LUAD	OR51Q1 →	+0.119	+3.188	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR1N2 →	+0.014	+3.189	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

TIFAB by CAMK4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →