CAMK2N1

Across TCGA pan-cancer cohorts, CAMK2N1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CAMK2N1 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CAMK2N1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CAMK2N1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

HNSC, KIRC, and LUSC are the cancer types where CAMK2N1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.590	0.727	<.001	153	view →
KIRC	DFS	Tertile	All	0.739	0.556	<.001	69	view →
LUSC	OS	Quartile	All	0.550	0.765	<.001	69	view →
SKCM	OS	Median	II,III,IV	0.400	0.219	<.001	67	view →
LUAD	OS	Quartile	All	0.737	0.859	.002	55	view →
THCA	DFS	Quartile	II,III,IV	0.884	0.202	.004	49	view →
COAD	OS	Median	III,IV	0.794	0.587	.004	41	view →
ACC	OS	Median	II,III,IV	0.939	0.761	.001	30	view →
CESC	DFS	Median	All	0.631	0.838	<.001	30	view →
LIHC	OS	Quartile	All	0.413	0.631	.004	30	view →
PAAD	OS	Median	II,III,IV	0.487	0.682	.001	26	view →
KIRP	DFS	Median	All	0.786	0.926	<.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CAMK2N1–HNSC (OS)

Open the HNSC breakdown →