CAMK2N1

Across TCGA pan-cancer cohorts, CAMK2N1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CAMK2N1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CAMK2N1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CAMK2N1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where CAMK2N1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAMK2N1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+3.714	<.001	11	view →
COAD	Female	All	−1.334	<.001	11	view →
KIRC	Female	II,III,IV	−1.051	<.001	11	view →
LUAD	Male	All	−1.279	<.001	9	view →
LUSC	Female	II,III,IV	−3.062	<.001	8	view →
LIHC	Male	II,III,IV	+1.040	<.001	8	view →
KIRP	All	All	−1.169	<.001	7	view →
READ	All	II,III,IV	−1.795	<.001	6	view →
BLCA	All	IV	+1.511	<.001	6	view →
STAD	Male	All	+1.052	.009	5	view →
HNSC	Female	IV	+2.118	<.001	4	view →
BRCA	All	II,III,IV	+0.356	.034	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CAMK2N1–THCA

Open the THCA breakdown →