CALM3

Across TCGA patient cohorts, CALM3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALM3-associated genes across cancer lineages are Fibronectin, Src, and VHL. Each is linked with CALM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALM3-to-partner and partner-to-CALM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by CALM3-low versus CALM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALM3→partner) and Y-score (partner→CALM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.415	-3.000	.029	.037	3	1
UCEC	Src →	-0.288	-3.000	.015	.037	3	1
UCEC	VHL →	-1.175	-3.000	.002	.037	3	1
UCEC	Tuberin →	+0.422	+2.817	.006	.036	2	1
UCEC	PDCD4 →	-0.652	-3.000	.016	.037	1	1
UCEC	Rab11 →	-0.165	-3.000	.049	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Fibronectin by CALM3 expression — UCEC

Explore this box plot interactively →