CALM3

Across TCGA pan-cancer cohorts, CALM3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CALM3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CALM3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CALM3 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where CALM3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALM3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.012	<.001	12	view →
KIRC	Female	All	+0.887	<.001	12	view →
LIHC	Female	II,III,IV	+1.136	<.001	8	view →
BRCA	All	III,IV	+0.571	<.001	8	view →
THCA	Male	III,IV	−0.551	.004	6	view →
CHOL	Male	All	+1.581	<.001	5	view →
STAD	All	II,III,IV	+0.534	.019	4	view →
COAD	All	All	−0.266	.003	4	view →
BLCA	Male	III,IV	−0.994	.023	3	view →
ESCA	All	All	+1.000	.011	2	view →
READ	Female	All	−0.855	<.001	2	view →
UCEC	All	All	−0.437	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CALM3–HNSC

Open the HNSC breakdown →