CALHM6-AS1

Across TCGA pan-cancer cohorts, CALHM6-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CALHM6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CALHM6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CALHM6-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUSC, and KICH are the cancer types where CALHM6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALHM6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.057	.008	4	view →
LUSC	Male	All	+0.076	.046	2	view →
KICH	All	All	−0.052	.022	2	view →
KIRC	Male	II,III,IV	+0.068	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CALHM6-AS1–HNSC

Open the HNSC breakdown →