CALHM5

Across TCGA patient cohorts, CALHM5 mutation is significantly associated with the RNA expression of many other genes, with 717 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CALHM5-associated genes across cancer lineages are RNU6-1313P, YTHDF3-AS1, and PSMB7P1. Each is linked with CALHM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CALHM5-to-partner and partner-to-CALHM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1313P grouped by CALHM5-low versus CALHM5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM5→partner) and Y-score (partner→CALHM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1313P →	+0.593	+7.741	<.001	.009	3	3
UCEC	YTHDF3-AS1 →	+0.840	+3.354	<.001	.005	3	2
BLCA	PSMB7P1 →	+0.104	+7.640	<.001	.009	3	2
SKCM	NDUFA4P2 →	+0.070	+2.578	.002	.007	3	2
UCEC	MTFP1 →	+0.670	+2.700	.001	.006	3	2
LUAD	MTND5P29 →	+0.100	+4.712	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 717 associations by consensus.

RNU6-1313P by CALHM5 expression — COAD

Explore this box plot interactively →