CALHM3

Across TCGA patient cohorts, CALHM3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALHM3-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and Ku80. Each is linked with CALHM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM3-to-partner and partner-to-CALHM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CALHM3-low versus CALHM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM3→partner) and Y-score (partner→CALHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.207	-3.321	<.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.178	-2.449	.003	.019	3	1
UCEC	Ku80 →	+0.269	+2.472	.018	.011	3	1
UCEC	MEK1 →	+0.452	+2.999	.010	.035	3	1
UCEC	Notch1 →	+0.203	+3.013	.002	.018	3	1
UCEC	Annexin-1 →	+0.807	+3.019	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

A-Raf_pS299 by CALHM3 expression — UCEC

Explore this box plot interactively →