CALHM3

Across TCGA cell cohorts, CALHM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,550 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CALHM3-associated GO terms across cancer lineages are Arp2/3 complex-mediated actin nucleation, Plasma membrane organization, and Substrate adhesion-dependent cell spreading. Each is linked with CALHM3 in more than 7 cancer types. Because this analysis shows association rather than direction, both CALHM3-to-partner and partner-to-CALHM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Arp2/3 complex-mediated actin nucleation grouped by CALHM3-low versus CALHM3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM3→partner) and Y-score (partner→CALHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Arp2/3 complex-mediated actin nucleation →	+0.102	+0.624	<.001	.002	3	7
LIVER	Plasma membrane organization →	+0.127	+1.412	.002	.006	2	8
OESOPHAGUS	Substrate adhesion-dependent cell spreading →	+0.130	+0.924	.002	.004	3	6
BLOOD_Myeloma	Regulation of protein localization to mitochondrion →	+0.100	+0.581	.006	.004	3	6
STOMACH	Glomerular epithelial cell development →	+0.261	+0.831	<.001	.001	3	6
OVARY	Regulation of purine nucleotide biosynthetic process →	+0.121	+0.699	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,550 associations by consensus.

Arp2/3 complex-mediated actin nucleation by CALHM3 expression — BREAST

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