CALHM3

Across TCGA cell cohorts, CALHM3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CALHM3-associated genes across cancer lineages are MAGEB4, SEPTIN14, and PRR27. Each is linked with CALHM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALHM3-to-partner and partner-to-CALHM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CALHM3-low versus CALHM3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALHM3→partner) and Y-score (partner→CALHM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.019	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	PRR27 →	+0.208	+4.054	<.001	.004	3	1
SKIN	CCDC172 →	+0.006	+5.415	<.001	.004	3	1
LUNG_SCLC	KRTAP4-5 →	+0.075	+5.029	<.001	.006	3	1
LUNG_SCLC	KRTAP4-2 →	+0.113	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MAGEB4 by CALHM3 expression — LARGE_INTESTINE

Explore this box plot interactively →