CALCRL

Across TCGA pan-cancer cohorts, CALCRL Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CALCRL data layer compared with 19 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CALCRL Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CALCRL expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, COAD, and LUSC are the cancer types where CALCRL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.612	.003	18	view →
COAD	OS	Median	All	0.423	0.806	.001	18	view →
LUSC	DFS	Median	All	0.079	0.792	<.001	18	view →
BRCA	OS	Median	III,IV	0.027	0.907	<.001	12	view →
SCLC	OS	Median	All	0.082	0.822	<.001	6	view →
SKCM	DFS	Median	III,IV	0.174	0.659	.007	6	view →
GBM	OS	Median	All	0.070	0.416	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CALCRL–UCEC (DFS)

Open the UCEC breakdown →