CALCRL

Across TCGA pan-cancer cohorts, CALCRL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CALCRL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CALCRL RNA is repressed in tumor relative to normal tissue. In most cancer types CALCRL is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, KIRC, and LUSC are the cancer types where CALCRL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CALCRL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−2.233	<.001	10	view →
KIRC	Female	All	+1.153	<.001	10	view →
LUSC	All	III,IV	−3.391	<.001	9	view →
LUAD	Female	III,IV	−3.040	<.001	9	view →
HNSC	Female	III,IV	+1.536	.001	7	view →
LIHC	All	II,III,IV	+0.953	<.001	7	view →
UCEC	All	All	−2.470	<.001	6	view →
ESCA	Male	All	+1.428	.003	2	view →
KIRP	Male	All	−0.622	.012	2	view →
STAD	All	II,III,IV	+0.455	.020	2	view →
CHOL	All	All	+1.084	.032	1	view →
READ	Female	All	−0.970	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CALCRL–KICH

Open the KICH breakdown →