CALCRL

Across TCGA patient cohorts, CALCRL mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CALCRL-associated genes across cancer lineages are XBP1, Tuberin, and ASNS. Each is linked with CALCRL in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCRL-to-partner and partner-to-CALCRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XBP1 grouped by CALCRL-low versus CALCRL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCRL→partner) and Y-score (partner→CALCRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	XBP1 →	+0.250	+2.700	.009	.005	3	2
UCEC	Tuberin →	+0.334	+2.807	<.001	<.001	3	2
UCEC	ASNS →	+0.382	+1.584	.003	.019	3	2
UCEC	Caspase-8 →	-0.237	-2.780	.008	.003	3	2
UCEC	C-Raf →	+0.112	+1.925	.029	.005	3	2
SKCM	A-Raf_pS299 →	+0.128	+4.247	.022	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

XBP1 by CALCRL expression — SKCM

Explore this box plot interactively →