CALCRL

Across TCGA cell cohorts, CALCRL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,012 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CALCRL-associated GO terms across cancer lineages are Neuroblast differentiation, Cytoplasmic translation, and Peptidyl-lysine modification. Each is linked with CALCRL in more than 8 cancer types. Because this analysis shows association rather than direction, both CALCRL-to-partner and partner-to-CALCRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuroblast differentiation grouped by CALCRL-low versus CALCRL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCRL→partner) and Y-score (partner→CALCRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Neuroblast differentiation →	+1.469	+2.595	.001	<.001	3	9
BLOOD_Leukemia	Cytoplasmic translation →	+0.045	+0.828	<.001	.001	3	7
OESOPHAGUS	Peptidyl-lysine modification →	+0.046	+0.933	.002	.004	3	6
OESOPHAGUS	Regulation of organelle assembly →	+0.038	+0.801	.008	.005	3	6
BONE	Response to sucrose →	+1.169	+2.441	.003	.001	3	6
BONE	Regulation of cytoplasmic translation →	+0.060	+1.582	.006	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,012 associations by consensus.

Neuroblast differentiation by CALCRL expression — BONE

Explore this box plot interactively →