CALCRL

Across TCGA cell cohorts, CALCRL mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CALCRL-associated genes across cancer lineages are LCE1F, TBX22, and GLB1L3. Each is linked with CALCRL in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCRL-to-partner and partner-to-CALCRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1F grouped by CALCRL-low versus CALCRL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCRL→partner) and Y-score (partner→CALCRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LCE1F →	+0.113	+4.662	<.001	.005	3	2
LARGE_INTESTINE	TBX22 →	+0.026	+3.217	<.001	.006	3	1
LARGE_INTESTINE	GLB1L3 →	+0.742	+3.716	<.001	.003	3	1
LARGE_INTESTINE	S100G →	+1.173	+3.103	<.001	.004	3	1
LARGE_INTESTINE	TFDP3 →	+0.028	+3.518	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

LCE1F by CALCRL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →