CALCB

Across TCGA patient cohorts, CALCB mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. SARC shows the largest number of these associations.

The most reproducible CALCB-associated genes across cancer lineages are SNORD109B, NEUROD6, and C11orf40. Each is linked with CALCB in more than 1 cancer types. Because this analysis shows association rather than direction, both CALCB-to-partner and partner-to-CALCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD109B grouped by CALCB-low versus CALCB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALCB→partner) and Y-score (partner→CALCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD109B →	+0.321	+4.884	<.001	.004	3	2
SARC	NEUROD6 →	+0.059	+5.224	<.001	.006	3	1
SARC	C11orf40 →	+0.086	+6.152	<.001	.001	3	1
SARC	KRTAP12-1 →	+0.094	+5.224	<.001	.006	3	1
SARC	KRTAP10-8 →	+0.143	+6.152	<.001	.001	3	1
SARC	CLEC20A →	+0.048	+5.224	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

SNORD109B by CALCB expression — SKCM

Explore this box plot interactively →