CAGE1

Across TCGA patient cohorts, CAGE1 mutation is significantly associated with the RNA expression of many other genes, with 2,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CAGE1-associated genes across cancer lineages are AATF, CENPM, and EMC9. Each is linked with CAGE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CAGE1-to-partner and partner-to-CAGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AATF grouped by CAGE1-low versus CAGE1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAGE1→partner) and Y-score (partner→CAGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AATF →	+0.376	+1.925	<.001	.009	3	3
UCEC	CENPM →	+0.626	+2.536	<.001	<.001	3	3
UCEC	EMC9 →	+0.442	+1.968	<.001	<.001	3	3
UCEC	RBFA →	+0.427	+1.721	<.001	.001	3	3
UCEC	AIMP2 →	+0.441	+2.609	.003	<.001	3	3
UCEC	PSMD3 →	+0.431	+2.233	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,712 associations by consensus.

AATF by CAGE1 expression — SKCM

Explore this box plot interactively →