CADPS

Across TCGA patient cohorts, CADPS mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CADPS-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and TIGAR. Each is linked with CADPS in more than 5 cancer types. Because this analysis shows association rather than direction, both CADPS-to-partner and partner-to-CADPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CADPS-low versus CADPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADPS→partner) and Y-score (partner→CADPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.309	+1.392	.019	.015	3	6
COAD	Caspase-7-cleavedD198 →	+1.053	+3.338	<.001	.004	3	5
LUSC	TIGAR →	+0.156	+1.750	.002	.049	3	4
UCEC	4E-BP1 →	+0.303	+3.392	<.001	<.001	3	4
UCEC	TFRC →	+0.548	+1.415	<.001	<.001	3	4
STAD	JNK2 →	+0.271	+3.000	.013	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

GAPDH by CADPS expression — UCEC

Explore this box plot interactively →