CADPS

Across TCGA pan-cancer cohorts, CADPS RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CADPS data layer compared with 8 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher CADPS RNA is associated with better overall survival. In most high-consensus cancer types, elevated CADPS expression acts as an unfavorable survival marker, although some lineages such as SCLC and CESC show a favorable association.

SCLC, BLCA, and THCA are the cancer types where CADPS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Quartile	All	0.803	0.378	.002	57	view →
BLCA	OS	Quartile	All	0.302	0.525	.002	36	view →
THCA	OS	Quartile	All	0.980	1.000	.004	35	view →
MESO	OS	Quartile	All	0.200	0.762	.006	33	view →
STAD	DFS	Median	III,IV	0.388	0.566	.006	25	view →
CESC	DFS	Median	IV	0.478	0.092	.010	24	view →
LGG	OS	Quartile	All	0.907	0.796	.002	24	view →
ACC	DFS	Quartile	All	0.578	0.131	.005	22	view →
UVM	DFS	Quartile	All	0.307	0.841	.010	21	view →
PAAD	DFS	Quartile	All	0.470	0.167	<.001	17	view →
THYM	DFS	Quartile	II,III,IV	0.682	0.936	.012	17	view →
OV	OS	Median	All	0.882	0.800	.008	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CADPS–SCLC (OS)

Open the SCLC breakdown →