CADPS

Across TCGA cell cohorts, CADPS mutation is significantly associated with the RNA expression of many other genes, with 504 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CADPS-associated genes across cancer lineages are SEPTIN12, TEX48, and TGM6. Each is linked with CADPS in more than 2 cancer types. Because this analysis shows association rather than direction, both CADPS-to-partner and partner-to-CADPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN12 grouped by CADPS-low versus CADPS-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADPS→partner) and Y-score (partner→CADPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SEPTIN12 →	+0.343	+3.506	.002	.006	3	3
KIDNEY	TEX48 →	+0.133	+5.000	<.001	.005	3	2
URINARY_TRACT	TGM6 →	+0.030	+3.050	.002	.007	3	2
URINARY_TRACT	SIGLEC14 →	+0.358	+3.506	.007	.006	3	2
LUNG_NSCLC_LUSC	TMEM114 →	+0.096	+4.643	<.001	.008	3	2
LUNG_SCLC	DTHD1 →	+0.025	+3.353	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 504 associations by consensus.

SEPTIN12 by CADPS expression — URINARY_TRACT

Explore this box plot interactively →