CAD

Across TCGA cell cohorts, CAD mutation is significantly associated with the RNA expression of many other genes, with 668 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CAD-associated genes across cancer lineages are ULBP1, OR2A14, and NOB1. Each is linked with CAD in more than 2 cancer types. Because this analysis shows association rather than direction, both CAD-to-partner and partner-to-CAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ULBP1 grouped by CAD-low versus CAD-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CAD→partner) and Y-score (partner→CAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ULBP1 →	+1.047	+3.355	.005	.007	3	3
BLOOD_Myeloma	OR2A14 →	+0.033	+4.807	<.001	.006	3	2
BLOOD_Leukemia	NOB1 →	+0.420	+3.489	.002	.001	3	2
BLOOD_Leukemia	LRRC38 →	+1.327	+2.531	<.001	.004	3	2
BLOOD_Leukemia	MTHFD2 →	+0.831	+3.489	.001	.001	3	2
BREAST	IL10 →	+0.042	+4.362	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 668 associations by consensus.

ULBP1 by CAD expression — SKIN

Explore this box plot interactively →