CAD

Across TCGA pan-cancer cohorts, CAD RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CAD’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CAD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CAD is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, STAD, and COAD are the cancer types where CAD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CAD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.457	<.001	12	view →
STAD	All	III,IV	+1.965	<.001	11	view →
COAD	Male	IV	+1.954	<.001	11	view →
KIRP	Male	II,III,IV	+1.356	<.001	11	view →
KIRC	All	All	+0.481	<.001	10	view →
LIHC	Male	II,III,IV	+1.844	<.001	9	view →
BLCA	Female	All	+1.556	<.001	9	view →
LUAD	All	III,IV	+1.402	<.001	9	view →
LUSC	Male	III,IV	+2.475	<.001	8	view →
CHOL	Male	All	+3.106	<.001	5	view →
READ	All	All	+1.362	<.001	5	view →
BRCA	All	II,III,IV	+0.325	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CAD–HNSC

Open the HNSC breakdown →