CACTIN

Across TCGA pan-cancer cohorts, CACTIN mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CACTIN data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CACTIN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CACTIN expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where CACTIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.919	0.649	.002	35	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.800	.014	21	view →
HNSC	DFS	Median	IV	0.620	0.914	.001	19	view →
GBM	OS	Median	All	0.550	0.270	.001	13	view →
COAD	DFS	Median	II,III,IV	1.000	0.874	.037	12	view →
PDAC	DFS	Tertile	IV	0.558	0.225	.024	3	view →
CCRCC	DFS	Tertile	All	0.856	0.622	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CACTIN–LSCC (OS)

Open the LSCC breakdown →