CACTIN

Across TCGA patient cohorts, CACTIN mutation is significantly associated with the RNA expression of many other genes, with 1,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACTIN-associated genes across cancer lineages are ERI1, NUP188, and AAGAB. Each is linked with CACTIN in more than 3 cancer types. Because this analysis shows association rather than direction, both CACTIN-to-partner and partner-to-CACTIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERI1 grouped by CACTIN-low versus CACTIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACTIN→partner) and Y-score (partner→CACTIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERI1 →	+0.676	+4.021	<.001	<.001	3	4
UCEC	NUP188 →	+0.488	+2.288	<.001	<.001	3	4
UCEC	AAGAB →	+0.374	+2.008	.002	.005	3	3
UCEC	LEPROTL1 →	+0.313	+3.008	.005	<.001	3	3
UCEC	KCTD9 →	+0.603	+2.069	<.001	<.001	3	3
UCEC	DOT1L →	+0.499	+2.080	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,659 associations by consensus.

ERI1 by CACTIN expression — UCEC

Explore this box plot interactively →