CACTIN

Across TCGA patient cohorts, CACTIN mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACTIN-associated genes across cancer lineages are mTOR_pS2448, PCNA, and Di-Ras3. Each is linked with CACTIN in more than 2 cancer types. Because this analysis shows association rather than direction, both CACTIN-to-partner and partner-to-CACTIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CACTIN-low versus CACTIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACTIN→partner) and Y-score (partner→CACTIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.179	-3.687	<.001	.001	3	3
UCEC	PCNA →	+0.204	+2.000	.007	.003	3	3
UCEC	Di-Ras3 →	-0.175	-3.794	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.080	-2.432	.024	.018	3	2
UCEC	eIF4E →	+0.174	+2.807	.019	.003	3	2
UCEC	A-Raf_pS299 →	-0.165	-2.000	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

mTOR_pS2448 by CACTIN expression — UCEC

Explore this box plot interactively →