CACTIN

Across TCGA cell cohorts, CACTIN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,899 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CACTIN-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Regulation of anaphase-promoting complex-dependent catabolic process, and Positive regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with CACTIN in more than 17 cancer types. Because this analysis shows association rather than direction, both CACTIN-to-partner and partner-to-CACTIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by CACTIN-low versus CACTIN-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CACTIN→partner) and Y-score (partner→CACTIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Subtelomeric heterochromatin formation →	+0.135	+1.045	<.001	<.001	3	18
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.164	+0.944	<.001	<.001	3	18
STOMACH	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.172	+0.691	<.001	<.001	3	18
BONE	Cytoplasm protein quality control →	+0.138	+0.837	<.001	<.001	3	17
OESOPHAGUS	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.164	+0.957	<.001	.002	3	17
UPPER_AERODIGESTIVE_TRACT	mRNA cis splicing, via spliceosome →	+0.097	+0.797	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,899 associations by consensus.

Subtelomeric heterochromatin formation by CACTIN expression — BONE

Explore this box plot interactively →