CACNG8

Across TCGA patient cohorts, CACNG8 mutation is significantly associated with the RNA expression of many other genes, with 140 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNG8-associated genes across cancer lineages are MTCYBP20, ADAM2, and CXorf66. Each is linked with CACNG8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNG8-to-partner and partner-to-CACNG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP20 grouped by CACNG8-low versus CACNG8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNG8→partner) and Y-score (partner→CACNG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTCYBP20 →	+0.140	+5.212	.003	.007	3	3
SCLC	ADAM2 →	+0.024	+5.624	<.001	.003	3	1
SCLC	CXorf66 →	+0.141	+5.624	<.001	.003	3	1
UCEC	IGHV1OR21-1 →	+0.896	+3.800	.001	.001	3	1
HNSC	TEX47 →	+0.048	+5.266	<.001	.001	3	1
HNSC	PATE1 →	+0.043	+4.565	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 140 associations by consensus.

MTCYBP20 by CACNG8 expression — COAD

Explore this box plot interactively →