CACNB4

Across TCGA patient cohorts, CACNB4 mutation is significantly associated with the RNA expression of many other genes, with 4,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNB4-associated genes across cancer lineages are LAS1L, PITPNC1, and SKA1. Each is linked with CACNB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNB4-to-partner and partner-to-CACNB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAS1L grouped by CACNB4-low versus CACNB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNB4→partner) and Y-score (partner→CACNB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAS1L →	+0.202	+1.301	.009	.002	3	3
UCEC	PITPNC1 →	+0.472	+2.074	<.001	.001	3	3
UCEC	SKA1 →	+0.626	+1.439	<.001	<.001	3	3
UCEC	GPKOW →	+0.343	+1.750	<.001	<.001	3	3
UCEC	TIPIN →	+0.483	+1.771	<.001	<.001	3	3
UCEC	RBFA →	+0.338	+1.301	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,490 associations by consensus.

LAS1L by CACNB4 expression — UCEC

Explore this box plot interactively →