CACNB4

Across TCGA pan-cancer cohorts, CACNB4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CACNB4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CACNB4 RNA is repressed in tumor relative to normal tissue. In most cancer types CACNB4 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where CACNB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNB4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−0.812	<.001	12	view →
LUAD	Female	III,IV	−1.251	<.001	9	view →
LUSC	Male	III,IV	−1.095	<.001	9	view →
KIRC	Male	All	−0.844	<.001	9	view →
BLCA	Male	IV	−1.932	.002	8	view →
THCA	Male	II,III,IV	−0.916	<.001	8	view →
KIRP	Male	All	−0.858	<.001	6	view →
BRCA	All	All	−0.427	<.001	6	view →
LIHC	Male	All	+0.311	<.001	6	view →
CHOL	All	All	+0.200	<.001	4	view →
ESCA	All	All	−0.522	.003	2	view →
PRAD	All	All	−0.387	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

CACNB4–HNSC

Open the HNSC breakdown →