CACNB3

Across TCGA pan-cancer cohorts, CACNB3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CACNB3 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CACNB3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CACNB3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

HNSC, CHOL, and UCEC are the cancer types where CACNB3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.165	0.686	<.001	32	view →
CHOL	DFS	Median	All	0.045	0.486	.009	15	view →
UCEC	DFS	Median	All	0.973	0.827	.014	8	view →
LUSC	DFS	Median	All	1.000	0.384	.037	4	view →
COAD	DFS	Median	All	0.490	0.786	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CACNB3–HNSC (OS)

Open the HNSC breakdown →