CACNB3

Across TCGA pan-cancer cohorts, CACNB3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CACNB3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CACNB3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CACNB3 is over-expressed in tumor.

KIRP, BLCA, and LIHC are the cancer types where CACNB3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNB3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+1.338	<.001	11	view →
BLCA	All	All	+0.992	<.001	9	view →
LIHC	Female	II,III,IV	+0.918	<.001	9	view →
LUAD	All	III,IV	+0.998	<.001	8	view →
HNSC	Male	All	+0.633	<.001	8	view →
COAD	All	All	+0.235	.006	7	view →
BRCA	All	III,IV	+1.340	<.001	6	view →
CHOL	Male	All	+2.771	<.001	5	view →
LUSC	All	All	+0.457	<.001	5	view →
STAD	All	All	+0.490	.044	2	view →
THCA	Female	All	+0.441	.001	2	view →
KIRC	All	All	+0.285	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CACNB3–KIRP

Open the KIRP breakdown →