CACNA2D4

Across TCGA patient cohorts, CACNA2D4 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA2D4-associated genes across cancer lineages are FoxM1, ACC1, and Heregulin. Each is linked with CACNA2D4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNA2D4-to-partner and partner-to-CACNA2D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by CACNA2D4-low versus CACNA2D4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D4→partner) and Y-score (partner→CACNA2D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.192	+1.502	.010	.028	3	3
SKCM	ACC1 →	+0.340	+3.584	.002	.002	3	3
UCEC	Heregulin →	-0.093	-1.401	.006	.041	3	3
UCEC	PCNA →	+0.229	+1.678	<.001	<.001	3	3
SKCM	TFRC →	+0.446	+1.874	.028	.047	3	3
SKCM	Tuberin_pT1462 →	+0.220	+1.700	.032	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

FoxM1 by CACNA2D4 expression — SKCM

Explore this box plot interactively →