CACNA2D4

Across TCGA cell cohorts, CACNA2D4 mutation is significantly associated with the RNA expression of many other genes, with 321 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA2D4-associated genes across cancer lineages are OR13J1, OR1L3, and PRPSAP2. Each is linked with CACNA2D4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNA2D4-to-partner and partner-to-CACNA2D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13J1 grouped by CACNA2D4-low versus CACNA2D4-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D4→partner) and Y-score (partner→CACNA2D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	OR13J1 →	+0.030	+3.662	<.001	.005	3	2
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	2
LARGE_INTESTINE	PRPSAP2 →	+0.577	+3.386	.003	.001	3	2
LARGE_INTESTINE	ZNF232 →	+0.799	+2.502	<.001	.005	3	2
LARGE_INTESTINE	MIS12 →	+0.600	+2.588	.001	.004	3	2
LARGE_INTESTINE	SIRT1 →	+0.609	+3.628	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 321 associations by consensus.

OR13J1 by CACNA2D4 expression — LIVER

Explore this box plot interactively →