CACNA2D3

Across TCGA patient cohorts, CACNA2D3 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA2D3-associated genes across cancer lineages are ATM, BRCA2, and ACVRL1. Each is linked with CACNA2D3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CACNA2D3-to-partner and partner-to-CACNA2D3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CACNA2D3-low versus CACNA2D3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D3→partner) and Y-score (partner→CACNA2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.370	-1.912	.001	.004	3	3
UCEC	BRCA2 →	-0.072	-0.946	.032	.028	3	3
STAD	ACVRL1 →	-0.179	-2.679	.040	.005	3	2
UCEC	C-Raf →	+0.138	+1.295	<.001	.008	3	2
UCEC	ERK2 →	+0.116	+1.523	.022	.006	3	2
SKCM	c-Met →	+0.068	+1.033	.047	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ATM by CACNA2D3 expression — UCEC

Explore this box plot interactively →