CACNA2D1

Across TCGA patient cohorts, CACNA2D1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA2D1-associated genes across cancer lineages are Caspase-7-cleavedD198, Rad50, and ATM. Each is linked with CACNA2D1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CACNA2D1-to-partner and partner-to-CACNA2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CACNA2D1-low versus CACNA2D1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D1→partner) and Y-score (partner→CACNA2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.020	+3.321	<.001	.009	3	4
UCEC	Rad50 →	-0.162	-1.378	.025	.008	3	4
UCEC	ATM →	-0.452	-1.378	<.001	.008	3	4
LUAD	Transglutaminase →	-0.282	-2.807	.020	.003	3	3
STAD	Src →	-0.330	-3.169	.010	.018	3	3
UCEC	Cyclin-B1 →	+0.770	+2.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by CACNA2D1 expression — COAD

Explore this box plot interactively →