CACNA2D1

Across TCGA pan-cancer cohorts, CACNA2D1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CACNA2D1 data layer compared with 12 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CACNA2D1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACNA2D1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PAAD show a favorable association.

UVM, BLCA, and BRCA are the cancer types where CACNA2D1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.256	0.833	<.001	130	view →
BLCA	OS	Median	All	0.536	0.683	<.001	114	view →
BRCA	DFS	Median	III,IV	0.620	0.268	<.001	63	view →
STAD	OS	Quartile	III,IV	0.402	0.634	.010	56	view →
KIRP	DFS	Median	II,III,IV	0.239	0.710	<.001	39	view →
SCLC	DFS	Tertile	All	0.531	1.000	.002	29	view →
PAAD	DFS	Median	All	0.556	0.408	.007	21	view →
PRAD	DFS	Tertile	All	0.970	0.906	<.001	20	view →
LGG	DFS	Quartile	All	0.888	0.770	.003	18	view →
SKCM	DFS	Quartile	All	0.271	0.131	.004	18	view →
HNSC	DFS	Median	IV	0.388	0.218	.003	14	view →
KIRC	DFS	Median	All	0.850	0.736	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CACNA2D1–UVM (DFS)

Open the UVM breakdown →