CACNA2D1

Across TCGA cell cohorts, CACNA2D1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,999 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CACNA2D1-associated GO terms across cancer lineages are Translational initiation, Bundle of His cell to Purkinje myocyte communication, and Positive regulation of cell cycle. Each is linked with CACNA2D1 in more than 9 cancer types. Because this analysis shows association rather than direction, both CACNA2D1-to-partner and partner-to-CACNA2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Translational initiation grouped by CACNA2D1-low versus CACNA2D1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D1→partner) and Y-score (partner→CACNA2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Translational initiation →	+0.061	+1.433	<.001	.007	3	10
PANCREAS	Bundle of His cell to Purkinje myocyte communication →	-0.232	-1.105	<.001	<.001	3	9
LIVER	Positive regulation of cell cycle →	+0.069	+2.224	<.001	<.001	3	9
BREAST	Inorganic anion transport →	-0.056	-0.819	.004	.001	3	9
LUNG_NSCLC_LUAD	Protein localization to cilium →	+0.059	+1.750	<.001	<.001	3	9
LUNG_SCLC	Translesion synthesis →	+0.098	+1.318	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,999 associations by consensus.

Translational initiation by CACNA2D1 expression — STOMACH

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