CACNA2D1

Across TCGA cell cohorts, CACNA2D1 mutation is significantly associated with the RNA expression of many other genes, with 1,161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA2D1-associated genes across cancer lineages are SMIM23, METTL4, and FANCD2. Each is linked with CACNA2D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNA2D1-to-partner and partner-to-CACNA2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by CACNA2D1-low versus CACNA2D1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D1→partner) and Y-score (partner→CACNA2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMIM23 →	+0.012	+4.247	<.001	.004	3	2
LARGE_INTESTINE	METTL4 →	+0.634	+3.067	<.001	.009	3	2
LARGE_INTESTINE	FANCD2 →	+0.694	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	PRIMPOL →	+0.650	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	FBXW10 →	+0.178	+3.392	.001	.002	3	2
LARGE_INTESTINE	FREM3 →	+0.083	+2.054	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,161 associations by consensus.

SMIM23 by CACNA2D1 expression — BLOOD_Leukemia

Explore this box plot interactively →