CACNA1S

Across TCGA pan-cancer cohorts, CACNA1S Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated CACNA1S data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CACNA1S Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA1S expression acts as an unfavorable survival marker, although some lineages such as STAD and OV show a favorable association.

THYM, STAD, and KICH are the cancer types where CACNA1S Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
STAD	DFS	Median	III,IV	0.891	0.315	.010	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
BRCA	OS	Median	III,IV	0.157	0.906	<.001	12	view →
ESCA	DFS	Median	All	0.127	0.541	<.001	12	view →
LUSC	OS	Median	III,IV	0.251	0.588	.009	12	view →
LIHC	OS	Median	All	0.031	0.775	<.001	9	view →
OV	OS	Median	III,IV	1.000	0.676	.026	6	view →
UCEC	DFS	Median	All	0.741	0.633	.032	6	view →
LUAD	OS	Median	All	0.102	0.383	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

CACNA1S–THYM (OS)

Open the THYM breakdown →