CACNA1I

Across TCGA pan-cancer cohorts, CACNA1I Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated CACNA1I data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CACNA1I Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CACNA1I expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, THYM, and ESCA are the cancer types where CACNA1I Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.820	<.001	36	view →
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
ESCA	OS	Median	All	0.157	0.708	<.001	15	view →
LIHC	OS	Median	II,III,IV	0.178	0.715	.011	15	view →
LUAD	OS	Median	III,IV	0.004	0.662	<.001	12	view →
LUSC	OS	Median	III,IV	0.054	0.768	<.001	10	view →
SKCM	OS	Median	III,IV	0.890	0.661	.021	7	view →
PRAD	DFS	Median	All	0.617	0.886	.041	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SCLC	OS	Median	All	0.916	0.598	.016	3	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

CACNA1I–UCEC (DFS)

Open the UCEC breakdown →